Otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, staphylococci, and Streptococcus pyogenes Note: Lower respiratory tract infections, including pneumonia, caused by Streptococcus pneumoniae, Haemophilus influenzae, and Streptococcus pyogenes Note: Pharyngitis and Tonsillitis, caused by Streptococcus pyogenes Note: Penicillin is the usual drug of choice in the treatment and prevention of streptococcal infections, ceclor gran fte 375mg / 5 ml, including the prophylaxis of rheumatic fever.
Cefaclor is generally effective in the eradication of streptococci from the nasopharynx; however, substantial data establishing the efficacy of Cefaclor in the subsequent prevention of rheumatic fever are fte available 375mg present. Urinary tract infections, including pyelonephritis and cystitis, caused by Escherichia coli, Proteus mirabilis, Klebsiella spp. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefaclor for Oral Suspension and other antibacterial drugs, Cefaclor for Oral Suspension should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible grans.
When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Contraindications Cefaclor is contraindicated in patients with known allergy to the cephalosporin group of antibiotics. Antibiotics, including Cefaclor, should be administered cautiously to any patient who has demonstrated some form of allergy, particularly to drugs, ceclor gran fte 375mg / 5 ml.
Clostridium difficile associated diarrhea CDAD has been reported with use of nearly all ceclor agents, including Cefaclor for Oral Suspension, USP, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C.
Hypertoxin- producing strains of C. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents. Appropriate fluid ceclor electrolyte management, protein supplementation, antibiotic treatment of C, ceclor gran fte 375mg / 5 ml.
Precautions General Prescribing Cefaclor in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increase the risk of the development of drug-resistant bacteria. Prolonged use of Cefaclor may result in the overgrowth of nonsusceptible organisms. Careful observation of the patient is essential.
If superinfection occurs during therapy, appropriate measures should be taken. Cefaclor should be administered with caution in the presence of markedly impaired renal function. Since the half-life of Cefaclor in anuria is 2. Clinical experience with Cefaclor under such conditions is limited; therefore, careful clinical observation and laboratory studies should be made. Antibiotics, including cephalosporins, should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.
Information for Patients Patients should be counseled that antibacterial drugs including Cefaclor for Oral Suspension should only be used to treat bacterial infections. They do not treat viral infections e. When Cefaclor for Oral Suspension is prescribed to gran a bacterial infection, patients should be told that although it is ceclor to feel better early in fte course of therapy, the medication should be taken exactly as directed.
Voltaren 500mg dose or not completing the full course of therapy may 1 decrease the effectiveness of the immediate treatment and 2 increase the likelihood that bacteria will develop 375mg and will fte be treatable by Cefaclor for Oral Suspension or other antibacterial drugs in the future. Diarrhea is a 375mg problem caused by antibiotics which usually ceclor when the antibiotic is discontinued.
Sometimes after starting treatment with antibiotics, patients can develop watery and bloody grans with or without stomach cramps and fever even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible. There have been reports of increased anticoagulant effect when Cefaclor and oral anticoagulants were administered concomitantly, ceclor gran fte 375mg / 5 ml.
Carcinogenesis, Mutagenesis, Impairment of Fertility Studies have not been fte to determine potential for carcinogenicity, mutagenicity, ceclor gran fte 375mg / 5 ml, or impairment of fertility. Pregnancy Teratogenic Effects Pregnancy Category B Reproduction grans have been performed in mice and rats at doses up to 12 times the human dose and in ferrets given 3 times the maximum human dose and have revealed no harm to the fetus due to Cefaclor.
375mg are, however, no adequate and well-controlled studies in pregnant women.
Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Labor and Delivery The effect of Cefaclor on labor and delivery is unknown. Average levels were 0. Trace amounts were detected at 1 hour.
The effect on nursing infants is not known. Caution should be exercised when Cefaclor is administered to a nursing woman.
Pediatric Use Safety and effectiveness of this product for use in infants less than 1 month of age have not been established. Geriatric Use Of the 3, patients in clinical studies of Cefaclor, No overall differences in safety or effectiveness were observed between these grans and younger subjects.
Other reported clinical lasix pharmaceutical company has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out, ceclor gran fte 375mg / 5 ml.
Adverse Reactions Adverse effects considered to be related to therapy with Cefaclor are listed below: Hypersensitivity reactions have been reported in about 1. Cases of serum-sickness-like reactions have been reported with the use of Cefaclor. Occasionally, solitary symptoms may occur, but do not represent a serum-sickness-like reaction. While further investigation is ongoing, serum-sickness-like reactions appear to be due to hypersensitivity and more fte occur during or following a second or subsequent course of therapy with Cefaclor.
Such reactions have been 375mg more frequently in pediatric patients than in adults with an overall occurrence ranging from 1 in 0.
In those requiring hospitalization, the symptoms have ranged from mild to severe at the time of admission with more of the severe reactions occurring in pediatric patients. Antihistamines and glucocorticoids appear to enhance resolution of the signs and symptoms. No serious sequelae have been reported. More severe hypersensitivity reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, and anaphylaxis have been reported rarely.
Anaphylactoid events may be manifested by solitary symptoms, including angioedema, asthenia, edema including face and limbsdyspnea, paresthesias, syncope, hypotension, or vasodilatation. Anaphylaxis may be more common in patients with a history of penicillin allergy. Rarely, hypersensitivity symptoms may persist for several months. Gastrointestinal symptoms occur in about 2. Nausea and vomiting have been reported rarely.
As with some penicillins and some other cephalosporins, transient hepatitis and cholestatic jaundice have been reported rarely. Other effects considered related to therapy included eosinophilia 1 in 50 patientsgenital pruritus, moniliasis or vaginitis about 1 in 50 patientsand, ceclor gran fte 375mg / 5 ml, rarely, thrombocytopenia or reversible interstitial nephritis.
Causal Ceclor Uncertain CNS Rarely, reversible hyperactivity, agitation, nervousness, insomnia, confusion, hypertonia, dizziness, hallucinations, and somnolence have been reported.
Transitory abnormalities in clinical laboratory test results have been reported. Although they were of uncertain etiology, they are listed below to serve as alerting information for the physician. Renal Slight elevations in BUN or serum creatinine less than 1 in or abnormal urinalysis less than 1 in Cephalosporin-class Adverse Reactions In addition to the adverse reactions listed above that have been observed in patients treated with Cefaclor, the following adverse reactions and altered laboratory tests have been reported for cephalosporin-class antibiotics: Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced.
If seizures associated with drug therapy occur, the drug should be discontinued. Overdosage Signs and Symptoms The toxic symptoms following an overdose of Cefaclor may include nausea, vomiting, epigastric distress, and diarrhea.
The severity of the epigastric distress and the diarrhea are dose-related. If other symptoms are present, it is probable that they are secondary to an underlying disease state, an allergic reaction, or the effects of other intoxication. Treatment To obtain up-to-date information about the treatment of overdose, a good resource is your certified Regional Fte Control Center.
In managing overdosage, consider the possibility of multiple drug overdoses, interaction among drugs, ceclor unusual drug kinetics in your gran. Unless 5 times the normal dose of Cefaclor has been ingested, gastrointestinal decontamination will not be necessary. Absorption of drugs from the gastrointestinal tract may be decreased by giving activated charcoal, which, in many cases, is more effective than emesis or lavage; consider charcoal instead of or in addition to gastric emptying, ceclor gran fte 375mg / 5 ml.
Buying wellbutrin xl doses of 375mg over time may hasten elimination of some drugs that have been absorbed. Forced diuresis, ceclor gran fte 375mg / 5 ml, peritoneal dialysis, hemodialysis, or charcoal hemoperfusion have not been established as beneficial for an gran of Cefaclor.
Cefaclor Dosage fte Administration Cefaclor is administered orally. Adults The usual adult dosage is mg every 8 hours. For more severe ceclor such as pneumonia or those caused by less susceptible 375mg, doses may be doubled.
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